Tumor cells penetrated by particles carrying genetic instructions.

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable nanoparticles able to carry DNA to brain cancer cells in mice. The team says the results of their proof of principle experiment suggest that such particles loaded with “death genes” might one day be given to brain cancer patients during neurosurgery to selectively kill off any remaining tumor cells without damaging no…

Often the best remedy for the winter blahs is to just jump into the cold and embrace it with a good workout. In Vermont, where they know a thing or two about getting outdoors, hotels in a couple of our favorite towns have dreamed up some imaginative cures to energize their guests before they pamper them.

The Woodstock Inn & Resort, in the center of the picturesque village of the same name, already has a Nordic center for cross-country skiing and a private ski mountain amusingly named Suicide Six that ha…

Children delivered by cesarean section and those given antibiotics during early infancy appear more prone to developing allergic inflammation of the esophagus — the muscular tube that connects the mouth to the stomach — according to results of a study by investigators from the Johns Hopkins Children’s Center and Harvard Medical School.

The findings, published online May 2 in the Journal of Allergy and Clinical Immunology: In Practice, reveal that early antibiotic treatment and C-section delivery may so…

Originally revealed at the 2014 Los Angeles Auto Show, the Audi Prologue concept made a follow-up appearance at January’s Consumer Electronics Show in Las Vegas, in a new gasoline-electric hybrid version that features Audi’s latest autonomous driving technology.

This revolutionary new concept, from its Matrix laser headlights to its low grille, is a bold opening gambit for Marc Lichte, Audi’s new chief designer. Inside the cockpit, flexible 3-D LED screens surround the driver. With a swipe of the hand, the …

New designs from the Hong Kong–based jeweler Wallace Chan pair a range of colorful gemstones with innovative setting and carving techniques in statement-making designs that command attention. Here we share a selection of our favorite designs. (wallace-chan.com)

The 72 dealers and galleries chosen to exhibit at the Art Show must bring their A games. Hosted by the Art Dealers Association of America at the Park Avenue Armory in Manhattan, the show is subject to space limitations that do not allow all 180 members of the association to take a booth. Many in the 2015 show, which takes place March 4 through 8, earned places on the strength of their promised displays, ensuring that everybody—especially the ticket-holding public—wins.

New York’s Galerie St. Etienne will ce…

Biomarkers may predict traumatic brain injury outcomes.

When it comes to predicting outcomes following a child’s traumatic brain injury, rehab physicians may have more questions than answers. After all, says Johns Hopkins pediatric physiatrist Stacy Suskauer, symptoms can last from hours to years, “and we lack objective biomarkers with which to predict outcome, inform treatment and evaluate the risk for chronic sequelae.”

Suskauer, who also directs Brain Injury Rehabilitation Programs at Johns Hopkins’ n…

In 1990, Aston Martin ended production of its Lagonda luxury sedan, largely remembered by auto critics as one of the ugliest and worst cars of the last 50 years. With a mere 645 examples, the Lagonda nameplate appeared to be gone for good. However, during its 16-year production run—and the subsequent years thereafter—the car developed a cultlike following among those with a very distinct taste for luxury goods and a particular penchant for four-door saloons. Recognizing this demand, Aston Martin recently annou…

A number of patients who need urgent surgery for ruptured aneurysms, brain traumas, brain tumors, or other neurological injuries need to have a portion of their skull removed that’s later replaced, necessitating a second operation, a “cranioplasty.” That second procedure puts them at risk of adding insult to injury and may leave them looking significantly different in comparison to their presurgical appearance, says Johns Hopkins’ neurosurgeon Judy Huang. Replacing the portion of missing skull at a later …

More than 170 exhibitors from around the globe will offer their collections—worth more than $1 billon in total—at this year’s Palm Beach Jewelry, Art & Antique Show. The Florida show’s 12th annual installment will be held over Presidents’ Day weekend, February 14 through 17, and will spotlight M. S. Rau Antiques’ $9.6 million Royal Blue ring, which features a 10-carat blue diamond set with pink diamonds. Other highlights include a circa-1870 Henry Dasson lacquered commode ($200,000 or more) presented by Bu…