Opened in October 2015, the Mark Hotel’s grand penthouse is the largest penthouse suite in the United States, clocking in at over 12,000 square feet (including 2,400 square feet of outdoor terrace space). Housed in a historic building from 1927 on New York’s Upper East Side, the two-story penthouse is designed like a private residence but is available for rent at $75,000 per night.

Inside are five bedrooms, six bathrooms, a library lounge, a full-size chef’s kitchen with a custom-made island, and a livi…